Xenical – a powerful, specific and reversible inhibitor of gastrointestinal lipases, which has a long-lasting effect. Its therapeutic effect is carried out in the lumen of the stomach and small intestine and consists in the formation of a covalent bond with the active serine portion of the gastric and pancreatic lipases. The inactivated enzyme at the same time loses the ability to break down food fats coming in the form of triglycerides, to sucking free fatty acids and monoglycerides. Since uncleaved triglycerides are not absorbed, the resulting decrease in the intake of calories into the body leads to a decrease in body weight. Thus, the therapeutic effect of the drug is carried out without absorption into the systemic circulation.
You should see some weight loss within 2 weeks after you start orlistat. Tell your doctor if your condition does not improve or if it worsens.
Orlistat, sold in Australia as Xenical, is a drug that’s promoted as a treatment for those who are overweight and obese. It works in your stomach and intestine by preventing your body from absorbing as much as 30% of the fat you eat, and as a result it can help you lose weight.
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